In the present invention, there is disclosed the use of sulfamate compounds of the general formula I, in which X represents the group CHi2 or an oxygen atom; Ri1 denotes a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms; and Ri2, Ri3, Ri4, Ri5 represent independently on each other a hydrogen atom or a lower alkyl group having 1 to 3 carbon atoms and when X is oxygen atom, Ri2 and Ri3 and/or Ri4 and Ri5 together may be a methylenedioxy group of the general formula II, in which Ri6 and Ri7 are the same or different and represent a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or Ri6 and Ri7 denote alkyl groups that are joined to form a cyclopentyl or cyclohexyl rings, wherein the compound of the general formula I is particularly topiramate, for preparing a medicament intended for the treatment of manic-depressive bipolar disorders in mammals.
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机译:在本发明中,公开了通式I的氨基磺酸酯化合物的用途,其中X代表基团CH 12或氧原子。 Ri 1表示氢原子或碳原子数1〜4的烷基。和Ri2,Ri3,Ri4,Ri5彼此独立地表示氢原子或具有1至3个碳原子的低级烷基,并且当X为氧原子时,Ri2和Ri3和/或Ri4和Ri5一起可以是亚甲基二氧基。通式II,其中Ri6和Ri7相同或不同并且代表氢原子,具有1-3个碳原子的低级烷基或Ri6和Ri7表示被连接形成环戊基或环己基环的烷基,其中通式I的化合物特别是托吡酯,用于制备用于治疗哺乳动物的躁狂抑郁性双相情感障碍的药物。
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