S-100蛋白在预测及评价心肺脑复苏后患者脑损害的意义

摘要

Objective To approach the anticipation and evaluation of S-100 protein for the patients with brain damage after cardiopulmonary-cerebral resuscitation(CPCR). Methods S-100 protein in blood serum of 40 patients with brain damage after CPCR were deteced by ELISA after 2h, 12h, 24h, 48h, 72h and 32 healthy controls. Results The level of serum S-100 protein in 40 patients after CPCR increased early and obviously, and be peaked from 2h (P<0.05). It was significance higher in each period than that in control group(P<0.01). Serum S-100 value at 2, 12, 24, 48 hour after resuscitation negatively correlated with GCS (P<0.01 or P<0.05). Conclusion S-100 protein can be a marker of the patients with brain damage after CPCR, it's high level cue to unfavurable prognosis. Also it was conducted to evaluate the pathogenetic condition of early coma patients after cardiac arrest.%目的 探讨S-100蛋白在心肺脑复苏患者中出现脑损害的预测及评价作用. 方法 用酶联免疫吸附法(ELISA)测定40例CPCR术后患者及32例对照者血清S-100蛋白浓度,并对其进行2小时、12小时、24小时、48小时、72小时的动态监测及比较.结果 40例心肺脑复苏后患者血清中的S-100蛋白浓度在早期明显升高,2小时达高峰,(P<0.05)各时间段浓度均显著高于对照组(P<0.01).2、12、24、48小时S-100水平与入院时GCS评分之间存在负相关关系(P<0.01或P<0.05).结论 S-100蛋白可作为心肺脑复苏后患者脑损伤的标志物,S-100蛋白水平高,提示预后不良,有助于心跳骤停后早期昏迷患者的病情评估.