血清铁蛋白、T淋巴细胞亚群在急性白血病患儿中的表达及临床意义

摘要

Objective To investigate the expression and clinical significance of serum ferritin and T lymphocyte subsets in patients with acute leukemia.Methods 68 children with acute leukemia in our hospital from January 2014 to December 2015 were divided into first diagnosed group (32 cases),stable group (20 cases),and recurrence group (16 cases) according to the different stages of the course of disease,and 30 healthy children were set as control group.Compared the differences of serum ferritin and T lymphocyte subsets in each group,and analyzed the clinical significance.Results The level of serum ferritin of first diagnosed group,stable group,and recurrence group were (645.7±78.2)μg/L,(394.8±73.9)μg/L,(682.7±101.7)μg/L,significantly higher than (122.2±26.3)μg/L of control group,and that of first diagnosed group and recurrence group were significantly higher than that of stable group (P＜0.05).The levels of CD3+,CD4+,and CD4+/CD8+ of children with acute leukemia were significantly lower than those of control group,and those of stable group were significantly higher than those of first diagnosed group and recurrence group (P＜0.05).Conclusion Serum ferritin and T lymphocyte subsets have specific guiding significance on clinical diagnosis and condition assessment in children with acute leukemia,with clinical application value.%目的 探讨急性白血病患者不同病程阶段血清铁蛋白、T淋巴细胞亚群水平的表达及临床意义.方法 选取本院2014年1月至2015年12月收治的68例急性白血病患儿,根据患儿病程阶段的不同分为初诊组32例、稳定组20例和复发组16例,选取30名同期健康体检儿童作为对照组.比较各组患者血清铁蛋白、T淋巴细胞亚群水平的差异,并对其临床意义进行分析.结果 初诊组、稳定组和复发组患儿的血清铁蛋白分别为(645.7±78.2) μg/L、(394.8±73.9) μg/L、(682.7±101.7) μg/L,明显高于对照组的(122.2±26.3) μg/L,且初诊组、复发组明显高于稳定组(P＜0.05);初诊组和复发组患儿CD3+、CD;及CD4+/CD8+水平均明显低于对照组,且稳定组患儿CD3+、CD4+及CD4+/CD8+水平明显高于初诊组和复发组(P＜0.05).结论 血清铁蛋白及T淋巴细胞亚群水平在急性白血病患儿的临床诊断和病情评估中存在明确的指导意义,具有临床应用价值.