ERG蛋白表达与前列腺癌患者根治术后生化复发风险关系的研究

摘要

目的 探讨临床局限性前列腺癌行根治性切除术后,组织ERG蛋白表达情况与术后生化复发的相关性.方法 选取2012年3月至2016年2月在本院治疗的121例局限性前列腺癌并行根治性切除术的患者作为研究对象,通过住院病历及门诊随访资料收集患者确诊时年龄、血清前列腺特异性抗原(PSA)水平、格里森评分(GS)、病理分期及切缘状态等参数.结果 共有98例患者完成最终随访,ERG蛋白表达阳性率为35.7％(35/98).Kaplan-meier生存分析提示,确诊时PSA水平(P =0.007)、GS(P=0.024)及ERG蛋白表达状态(P ＜0.0001),与术后生化复发相关.Cox回归多因素分析显示,确诊时PSA水平(HR =2.134,P=0.001)、GS(HR=1.361,P=0.030)及ERG蛋白表达状态(HR=2.024,P=0.044)分别为前列腺癌根治性切除术后生化复发的独立危险因素.结论 ERG蛋白表达状态是前列腺根治性切除术后生化复发的独立危险因素,通过对其检测及分析,可以为患者制定个体化的随访及临床治疗方案提供参考依据.%Objective To investigate the correlation between the expression of ERG protein and the postoperative biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.Methods A total of 121 patients from March 2012 to February 2016 diagnosed clinically localized prostate cancer were recruited into the study.Parameters such as age at diagnosis,prostate-specific antigen(PSA) level at diagnosis,gleason score (GS),pathological stage,surgical margin were collected retrospectively.Results A total of 98 patients completed the final follow-up,35.7％ of the patients were found ERG protein positive(35/98).Kaplan-meier survival analysis showed that PSA level (P =0.007),GS (P =0.024) and ERG protein expression (P ＜0.0001) were correlated with postoperative biochemical recurrence.PSA levels (HR =2.134,P =0.001),GS (HR =1.361,P =0.030) and ERG protein expression (HR =2.024,P =0.044) were significant in predicting biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.Conclusions ERG protein expression increases the risk of postoperative biochemical recurrence for prostate cancer,independent of known clinicopathological factors.