粪肠球菌可在恶劣的环境中持续生长和繁殖，而在生物膜中具有的极强的生存和致病能力，使其成为根尖周炎复发的重要的致病因素。粪肠球菌的毒力因子，可引起健康组织损伤，增强细菌的黏附能力。粪肠球菌的检出率，在原发性感染根管内为7.5%，但在治疗失败的感染根管中可达到70％以上，即粪肠球菌在原发性根尖周炎患牙的根管内并非主要致病菌。粪肠球菌在根管冠1/3段的感染较重，在根中1/3和根尖1/3段的感染较轻。粪肠球菌对常规的根管消毒和抗菌药物有极强的耐药性，很难用传统的方法将其于根管内彻底清除，因此研发可以有效地抑制或杀灭粪肠球菌药物十分必要。%Enterococcus faecalis(E.faecalis) survive and proliferate in very harsh environments. These bacteria have astrong capability for survival and pathogenesis in the biofilm, thus making them an important pathogenic factor in the recurrence of periapical periodontitis. The virulence factors of E.faecalis cause damage healthy tissues and enhance bacterial adhesion. In this study, the E.faecalis detection rate in an untreated root canal is 7.5%and reaches 70%in teeth with failed endodontic treatment. Therefore, E.faecalis in an untreated root canal is not the major pathogenic bacteria. E.faecalis heavily infects the crown of one root canal, whereas minimal infection is found in the middle third and the apical third of another root canal. E.faecalis is also resistant against common preparation methods and disinfection drugs, thuslendingdifficultytotheclearingoftherootcanal.Hence,adrugthateffectivelyinhibitsorkills E.faecalis should be developed.
展开▼
