氧化应激与孤独症

摘要

Autism in children is a complex disease of developmental disorder in nervous system,characterized by social deficits,impaired language and communication,stereotyped and repetitive behaviors.Studies indicate oxidative stress is associated with autism.Because of genic and environmental factors,children with autism are susceptible to oxidative stress.Oxidative stress induce the development of autism through abnormal metabolism of the membrane lipid,inflammation and excitotoxicity,autoimmunity,energy metabolism disorder,et al.Anti-oxidation might be a safe and effective therapy for autism.%孤独症是一种复杂的神经发育障碍性疾病,以社会交往障碍、语言交流障碍和刻板重复行为等为特征.研究表明,氧化应激与孤独症发病密切相关.基因与环境因素共同导致孤独症的氧化应激易患性.氧化应激通过膜脂代谢异常、炎症反应和兴奋毒性损伤、过度免疫以及能量代谢障碍等机制引发孤独症.抗氧化治疗是一种安全有效的治疗孤独症的方法.