白血病靶向治疗的研究进展

摘要

在过去的几十年中,白血病的疗效已经取得了显著改善.但难治性儿童急性淋巴细胞白血病及50％左右的急性髓系白血病的疗效还有待提高.目前,针对白血病独特发病环节的靶向治疗成为研究热点,包括以细胞表面分子为靶点的抗体药物、以激酶为靶点的药物等.很多药物如伊马替尼、硼替佐米等因其较好的临床效果已被应用于临床.%Over the past few decades,the curative effect of leukemia has been improved significantly.But the effect of refractory acute lymphoblastic leukemia and about 50％ of acute myeloid leukemia has not been improved.At present,targeted therapy,which is unique to the incidence of leukemia,has become a hotspot,such as the antibody drugs targeted cell surface molecules or kinases.At the same time,many drugs have been applied into clinical treatment because of their better clinical results,such as imatinib,bortezomib.