单胺能系统与HPA轴在注意缺陷多动障碍中的交互作用

摘要

注意缺陷多动障碍是儿童时期常见的神经行为疾病之一,患儿常表现为注意力易分散、过度活动、情绪冲动、认知障碍和学习困难,可严重影响学习和生活.关于注意缺陷多动障碍的具体发病机制尚未完全阐明.近年来,相关研究表明在注意缺陷多动障碍中,单胺能系统与下丘脑-垂体-肾上腺皮质(hypothalamic-pituitary-adrenal,HPA)轴之间存在某些交互作用,且其机制与转录因子Sp1、KLF11、R1等相关.该文就单胺能系统与HPA轴在注意缺陷多动障碍中的交互作用及相关转录因子进行综述.%Attention deficit hyperactivity disorder (ADHD) is one of the common neurodevelopmental disorders in childhood characterized by inattention,hyperactivity,impulsivity,cognitive impairment and learning difficulties and has a negative effect on children.The specific pathogenesis of ADHD is not fully clear.Recent studies have found that there are interactions between monoaminergic system and hypothalamic-pituitary-adrenal axis,in which the machanism is associated with transcription factors,such as Spl、KLF11、R1.This article reviews the characteristics of the monoaminergic system and hypothalamic-pituitary-adrenal axis in attention deficit hyperactivity disorder,and the machanism with transcription factors.