Evidence for Monoaminergic Involvement in Triadimefon-Induced Hyperactivity

摘要

Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, the effects of combined treatment of triadimefon with either the tyrosine hydroxlase inhibitor d,l-alpha-methyl-p-tyrosine methyl ester HCl (alphaMPT) or the amine depletor reserpine were evaluated. Adult male Long-Evans hooded rats, approximately 70 days of age were used. Dosage-effect functions were determined for alphaMPT (0-200 mg/kg IP), reserpine (0-2.5 mg/kg IP), d-amphetamine (0-3 mg/kg IP), and methylphenidate (0-40 mg/kg IP). Motor activity was measured as photocell interruptions in figure-eight mazes. The interaction between triadimefon and alphaMPT was determined with the following groups: (1) vehicle control; (2) 200 mg/kg triadimefon PO; (3) 100 mg/kg alphaMPT; and (40 both alphaMPT and triadimefon. A similar design was used to determine the interaction between triadimefon and reserpine (0.62 mg/kg) alphaMPT and d-amphetamine (1.5 mg/kg), and reserpine and methylphenidate (5.0 mg/kg). (Copyright (c) Springer-Verlag 1989.)