SUMO化修饰在肺部疾病中的作用

摘要

Small ubiquitin-related modifier(SUMO) is a small molecule that is structurally similar to ubiquitin.SUMOylation has emerged as an important post-translational modification.It profoundly influences the function of proteins,including the regulation of protein-protein interaction,the activity of protein transcription,DNA damage repair,gene regulation and biological rhythm.In recent years,evidence suggests that the SUMOylation plays crucial roles in lung.By binding to target proteins,SUMO is associated with pulmonary biological function and disease.%小泛素(small ubiquitin-related modifier,SUMO)是一种结构上与泛素相似的分子,作为一种重要的翻译后修饰,SUMO化修饰对蛋白质功能有广泛调节作用,包括调节蛋白间相互作用、蛋白转录活性、DNA损伤修复、基因稳定性调节及生物节律等.近年来,SUMO化修饰在肺脏中的作用逐渐被发现,SUMO通过与靶蛋白结合作用于肺,并与肺生物学功能和肺脏疾病有所关联.