Objective To evaluate the diagnostic value of independ or combined detection of carcinoembryonic antigen(CEA),cancer antigen-199(CA199)and cancer antigen 724(CA724)in gastric juice for the diagnosis of gastric cancer. Methods The levels of CEA,CA199 and CA724 in gastric juice samples from patients with gastric cancer or benign gastrosia were detected by using electrochemiluminescence(ECL). Results The positive rates of CEA,CA199 and CA724 were 35.7％, 50.0％ and 50.0％ sepa rarely in samples form patients with gastric cancer,with the positive rate of the combined detection of CEA and CA199 was 57. l％,of CEA and CA724 was 71.4％ ,and of CA199 and CA724 was 64.3％. But the positive rate of combined detectioin of the three markers combinedly was 71.4％. Conclusion The detection of CEA,CA199 and CA724 could be valuable for the diagnosis of gas tric cancer and combined detection of CEA and CA724 could significantly improve the diagnostic sensitivity.%目的 探讨胃液CEA、CA199、CA724单项检测或联合检测在胃癌诊断中的价值.方法 采用电化学发光技术,检测胃癌、良性胃疾病患者胃液中CA724、CA199、CEA浓度.结果 胃癌患者胃液中CEA、CA199、CA724阳性率分别为35.7%、50.0%、50.0%,CEA、CA199联合检测阳性率为57.1%,CEA、CA724联合检测阳性率为71.4%,CA199、CA724联合检测阳性率为64.3%,3项联合检测阳性率为71.4%.结论 胃液中CEA、CA199、CA724检测有助于胃癌的诊断,CEA、CA724联合检测可明显提高诊断的敏感性.
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