胃液及血清CA724,CA199和CEA联合检测对胃癌诊断的意义

摘要

目的 探讨胃癌患者胃液及血清CA724,CA199和CEA联合检测在胃癌诊断及其与良性胃疾病鉴别诊断中的临床价值.方法 用电化学发光法分别检测胃癌、良性胃疾病患者胃液、血清中CA724,CA199和CEA浓度.结果 胃癌患者胃液及血清中CEA,CA199和CA724阳性率与胃良性疾病患者的阳性率比较差异有统计学显著性意义(P<0.05);两种标本、三个项目联合检测敏感度为78.6%,显著高于单项、血清标本联合、胃液标本联合检测(P<0.05);两种标本、三个项目联合检测时,2项(69.0%)、3项(95.2%)、5项(100.0%)同时阳性,特异度高于1项阳性(44.2%).结论 胃液及血清CA724,CA199和CEA的联合检测可以提高胃癌的早期诊断,利用多项目同时阳性可增加特异度.%Objective To investigate the clinical value of cancer antigen-724(CA724),cancer antigen-199(CA199) and carcinoembryanic antigen(CEA) tests with a combined style for gastric cancer and benign gasrrosia. Methods The levels of CA724 ,CA199 and CEA in gastric juice and blood serum were detected by using electrochemiluminescence (ECL). Results Compared with benign gastrosia, there weresignificant deviation in the positive rate of CEA ,CA199 and CA724 in gastric patients , gastric juice and blood serum. Combination detection sensitivity of blood serum and gastric juice was the highest in the parallel experiment (78. 6％ );and the sequence experiment showed that two items or above positive markedly increased the diagnostic specificity. Conclusion The combined detection of CA724,CA199 and CEA could improve diagnosis sensitivity for gastric cancer,and two items or above positive could improve diagnosis specificity for gastric cancer.