Value and significance of tumor markers as CEA, CA125, SCC-Ag, CA199 and CYFRA21-1 in the diagnosis of cervical cancer

摘要

Objective: To investigate the value and significance of serum CEA, CA125, SCC-Ag, CA199and CYFRA21-1 in the diagnosis of cervical cancer by comparing the detection of five serummarkers. Methods: A total of 108 cases were divided into three groups, including 60 cervicalcancerpatients and 20 cervical intraepithelial neoplasiain patients treated in our hospital fromSeptember 2015 to September 2016 and 28 healthy women. Radioimmunoassay was usedto detect and compare the serum levels of CA125, CA199, CYFRA21-1 and ELISA methodwas used to detect and compare the serum levels of SCC-Ag, CEA. Results: (1) There was nostatistically significant difference in the serum CEA, CA125, SCC-Ag, CA199, CYFRA21-1levels between CIN group and control group. The serums CEA, CA125, SCC-Ag, CA199,CYFRA21-1 levels of cervical cancer patients were significantly higher than the other twogroups. The differences were statistically significant. (2)There were statistically significantdifferences in the serum CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levels between differentcervical pathological type groups.The serum CA125, CA199, CEA levels of cervical glandularcancer patients were significantly higher than the other two groups. The differences werestatistically significant. The serum SCC-Ag, CYFRA21-1 levels of cervical squamous cancerpatients were significantly higher than the other two groups. The differences were statisticallysignificant. Conclusion: The serums CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levelsof cervical cancer patients were significantly higher than cervical intraepithelial neoplasiainpatients and healthy women. The serum CA125, CA199, CEA levels of cervical glandularcancer patients were significantly higher and the serum SCC-Ag, CYFRA21-1 levels ofcervical squamous cancer patients were significantly higher. The five tumor markers canbe used in diagnosis of cervical cancer and they are also worthy in distinguishing cervicalpathological types.