1764例孕妇孕中期产前筛查结果分析

摘要

目的 通过检测孕妇血清甲胎蛋白(AFP)、游离β-人绒毛膜促性腺激素(β-HCG)水平进行孕中期胎儿无创伤性产前筛查.方法 采用化学发光法对1 764例孕中期孕妇进行血清AFP、fβ-HCG定量检测,计算风险值.结果 1 764例孕妇唐氏综合征(DS)、爱德华氏综合征(ES)、先天性神经管缺陷(NTD)筛查阳性率分别为3.51％(62/1 764)、0.11％(2/1 764)、2.49％(44/1 764).在不同年龄的高风险分组中,大于或等于35岁组与其他组DS筛查阳性率差异有统计学意义(P＜0.05),各年龄组NTD筛查阳性率无统计学差异(P＞0.05).结论 产前筛查是一种无创伤性检测手段,对避免DS、ES、NTD患儿出生有重要意义.%Objective To perform non-invasive prenatal screening at the second trimester by detectingorfetoprotein(AFP) and free β-human chorionic gonadotrophin(β-HCG).Methods AFP and fβ-HCG of 1 764 pregnant women at the second trimester were detected by chemiluminescence and the risk value was calculated.Results Positive rates of Down's syndrome(DS),Edward's syn-drome(ES) and neural tube defects(NTD) were 3.51% (62/1 764), 0.11% (2/1 764) and 2.49% (44/1 764).In different age groups,the positive rate of DS in the group of at least 35 years old was higher than other groups(P<0.05) ,but without statistical difference of NTD between different groups(P>0.05).Conclusion Prenatal screening could be a non-invasive detection methods and might be helpful for reducing the birth rate of DS,ES and NTD cases.