深圳地区儿童 MP实验室常规检测及分子流行病学特征

摘要

目的：分析深圳地区2010～2012年该院门诊及住院患儿肺炎支原体（M P ）感染分子流行病学特征，探讨实验室常规检测结果在M P感染诊断中的意义。方法选取2010～2012年诊断为呼吸道感染患儿，筛选出M P感染及非M P感染。对M P感染患儿3年间性别、年龄等流行病学特征进行分析，比较MP感染及非MP感染实验室常规检测及超敏C反应蛋白水平的差异。结果男性MP-DNA阳性检出率略高于女性，差异无统计学意义（P＞0．05）；MP感染在不同年龄群体均有发生，小于1岁MP-DNA阳性检出率最低，3～＜6岁患儿MP-DNA检出率最高（P＜0．05）；实验室常规检测及超敏C反应蛋白水平在MP感染诊断中无特异度。结论深圳地区MP分子流行病学显示MP感染具有季节性，实验室常规检测及超敏C反应蛋白水平不能作为MP实验室诊断的依据。%Objective To analyze the epidemiological characteristics of mycoplasma pneumoniae (MP) infection among the out-patients and inpatients children in Shenzhen area during 2010-2012 and to explore the significance of the results of the laboratory routine tests in the diagnosis of MP infection .Methods The children patients with respiratory tract infection from 2010 to 2012 were selected and the MP infection and the non-MP infection were screened out .The epidemiological characteristics of gender ,age , etc .,among the children patients with MP infection during these 3 years were analyzed .The differences in the laboratory routine tests and high sensitivity C reactive protein (hsCRP) were compared between the MP infection and the non-MP infection .Results The positive detection rate of MP-DNA in males was slightly higher than that in females ,the difference had no statistical signifi-cance (P>0 .05);MP infection occurred in different age groups ,the positive detection rate of MP-DNA was lowest in the children patients aged <1 year old and highest in the children patients aged 3 - < 6 years (P< 0 .05);the routine laboratory tests and hsCRP level had no specificity in the diagnosis of MP infection .Conclusion The MP molecular epidemiology in Shenzhen area shows that MP infection has the seasonality ,the laboratory routine tests and hsCRP level can not be used as the basis of the MP la-boratory diagnosis .