扩张性心肌病患者血液红细胞分布宽度改变与血清炎性因子之间的关系

摘要

目的：探讨扩张性心肌病（DCM ）患者血液红细胞分布宽度（RDW ）改变与血清炎性因子水平之间的关系。方法选取47例DCM患者（DCM组）和40例健康志愿者（对照组），依据纽约心脏病协会（NYHA）标准，47例DCM 患者中含NYHA Ⅱ级12例、NYHA Ⅲ级15例、NYHA Ⅳ级20例。测定上述人群RDW及超敏C‐反应蛋白（hs‐CRP）、肿瘤坏死因子α（TNF‐α）及白细胞介素1β（IL‐1β）等炎性因子水平，并分析RDW与血清炎性因子水平之间的相关性。结果与对照组比较，DCM组患者血液RDW、hs‐CRP、TNF‐α及IL‐1β水平均升高，差异均有统计学意义（P＜0．05）；DCM分级组间比较显示，NYHA Ⅲ级及NYHAⅣ级患者血液RDW、hs‐CRP、TNF‐α、IL‐1β水平高于NYHA Ⅱ级，差异均有统计学意义（P＜0．05）；DCM 患者中血液RDW与hs‐CRP、TNF‐α、IL‐1β均呈正相关（r分别为0．422、0．390、0．325，P＜0．05）。结论血液RDW是评估DCM 患者心功能指标之一，与患者血清炎性因子水平具有相关性。%Objective To investigate the relationship between red cell distribution (RDW) and serum inflammatory factor in di‐lated cardiomyopathy (DCM ) patients .Methods 47 dilated cardiomyopathy patients and 40 healthy volunteers were chosen .Ac‐cording to NYHA classification ,12 patients in NYHA class Ⅱ ,15 patients in NYHA class Ⅲ and 20 patients in NYHA class Ⅳ . RDW ,High sensitivity C‐reaction protein (hs‐CPR) ,tumor necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) were detected in all the DCM patients and healthy volunteers .The correlation between RDW and serum inflammatory factors were analyzed . Results Compared to healthy volunteers ,RDW ,hs‐CRP ,TNF‐α and IL‐1β were elevated significantly in DCM patients (all P<0 .05) .Comparisons among the DCM patients groups ,RDW ,hs‐CRP ,TNF‐α,IL‐1β in NYHA class Ⅲ and NYHA class Ⅳ were higher than those in NYHA class Ⅱ(all P<0 .05) .There were positive correlation between RDW and hs‐CRP ,RDW and TNF‐α, RDW and IL‐1β(r=0 .422 ,0 .390 ,0 .325 ,P<0 .05) .Conclusion RDW is one of the indicators evaluating cardiac functions ,and there is a significant correlation between RDW and serum inflammatory factors in DCM patients .