抗凝血酶Ⅲ活性检测对肝硬化分级患者血栓风险评估的价值

摘要

Objective To investigate the relationship of antithrombin‐Ⅲ activity and thrombosis risk in liver cirrhosis with Child‐Pugh classification .Methods In our hospital from June to December 2014 ,60 liver cirrhosis patients were selected randomly included into this experiment group ,The 60 cases of control group were from medical examination of health in our hospital .The plasma AT‐Ⅲ activity and D‐D concentration in all these cases were detected and analyzed .Results The AT‐Ⅲ in cirrhosis patients were significantly lower than which in healthy persons(P<0 .05) .The lower level of AT‐Ⅲ is in these patients which were in seri‐ous condition(P<0 .05) ,the abnormal rate of D‐D concentration is also higher at the same time(P<0 .05) .Conclusion The detec‐tion of AT‐Ⅲ level in patients with liver cirrhosis is directly related to the severity of clinical and thrombosis risk .The AT‐Ⅲ de‐tection level can be used to judge the patient′s condition and develop appropriate treatment strategies .%目的：探讨血浆抗凝血酶Ⅲ（AT‐Ⅲ）活性在评价乙型肝炎肝硬化Child‐Pugh分级患者血栓形成风险中的价值，为疾病诊断和治疗提供参考依据。方法从2014年6～12月该院乙型肝炎住院患者中随机选取60例作为试验组，并按Child‐Pugh分级分组；另从同期体检健康人群中随机选取60例作为健康对照组，分别检测血浆A T‐Ⅲ的活性和D‐二聚体水平，并做统计学分析。结果乙型肝炎肝硬化试验组患者血浆AT‐Ⅲ活性水平明显低于健康对照组（P＜0．05），Child‐Pugh分级A、B、C级3组中AT‐Ⅲ活性水平逐级降低，A、B、C级各组间比较，异常率和活性水平差异有统计学意义（P＜0．05），同时，D‐二聚体异常率逐渐增高，A、B、C级各组间比较差异有统计学意义（P＜0．05）。结论血浆AT‐Ⅲ水平与乙型肝炎肝硬化患者病情严重程度直接相关，并可增加患者血栓发生率，临床可以根据血浆AT‐Ⅲ水平判断乙型肝炎肝硬化患者病情发展及血栓形成的风险。