目的：观察妊娠期糖尿病（GDM）患者血清脂肪因子 Omentin-1水平变化，并探讨其临床意义。方法采用酶联免疫吸附测定（ELISA）法定量85例GDM及匹配设置的85例糖耐量正常孕妇（NGT）血清Omentin-1水平，同时检测两组糖脂生化指标、炎性指标、空腹胰岛素（FINS）水平，计算胰岛素抵抗指数（HOMA-IR）。结果 GDM组孕前体质量指数（BMI）、超敏-C 反应蛋白（hs-CRP）、血脂、血糖、FINS 及 HOMA-IR 均明显高于 NGT 组，血清 Omentin-1明显低于 NGT 组，差异有统计学意义（P＜0．05）。产前肥胖和／或 HOMA-IR≥2时，血清Omentin-1水平明显降低。血清Omentin-1与高密度脂蛋白（HDL）呈正相关，而与孕前BMI、产前 BMI、FPG、FINS 及 HOMA-IR 呈负相关。多元逐步回归分析孕前 BMI、三酰甘油（TG）、空腹血糖（FPG）、FINS是GDM血清Omentin-1的独立影响因素。结论血清Omentin-1与GDM关系密切，反映孕妇糖、脂代谢紊乱和胰岛素抵抗程度，可能直接参与了GDM疾病的发生和发展。%Objective To observe the change of serum Omentin-1 in gestational diabetes mellitus(GDM)and to investigate its clinical significance.Methods Serum Omentin-1 level was detected in 85 cases of GDM and 85 matched cases of normal glucose tol-erance(NGT)by ELISA,the glycolipids biochemical indexes,inflammation indexes and fasting insulin (FINS)level were simultane-ous detected,then the insulin resistance index (HOMA-IR)was calculated in both groups.Results The levels of prenatal prepreg-nant BMI,FPG,hs-CRP,blood lipids,blood glucose,FINS and HOMA-IR in the GDM group were significantly higher than those in the NGT group,while serum Omentin-1 level was obviously lower than that in the NGT group,difference was statistically signifi-cant (P<0.05);when prenatal obesity and/or HOMA-IR≥2,the serum Omentin-1 levels was significantly decreased.Serum Omentin-1 level had significant positive correlation with HDL,and negative correlation with prepregnant BMI,prenatal BMI,FPG, FINS and HOMA-IR.The multiple stepwise regression analysis showed that prepregnant BMI,TG,FPG and FINS were independ-ent influencing factors of serum Omentin-1 in GDM.Conclusion Serum Omentin-1 is associated with GDM closely,which can re-flect the degrees of sugar,lipid metabolic disorder and insulin resistance in pregnant women,and may be involved in the occurrence and development of GDM.
展开▼
