玻璃体腔注射曲安奈德减轻视网膜静脉阻塞继发的黄斑水肿

摘要

AIM: To assess the long-term safety and efficacy of intravitreal triamcinolone acetonide (TA) injection in the management of macular edema caused by retinal vein occlusion (RVO).METHODS: This prospective, interventional case series included 17 patients (17 eyes) with RVO and macular edema. They received an intravitreal injection of 2mg TA. Follow-up was for 1 year. Outcome measures were visual acuity and macular thickness measured using ocular coherence tomography (OCT).RESULTS: In our group, visual acuity measurements showed that 15 eyes (88%) had improved visual acuity, and mean visual acuity increased from 0. 114 ± 0. 068 preoperatively to a postoperative visual acuity of 0. 184 ± 0. 094 ( P < 0. 05 ). The central macular thickness was reduced from 514.0±67. 4μm to 442. 0 ± 61. 5μm( P<0. 05). Six patients in the study suffered a rise in intraocular pressure (IOP) (35%) temporarily. There was no case of visually significant cataract, vitreous haemorrhage, retinal detachment, or endophthalmitis.CONCLUSION; Intravitreal injection of triamcinolone acetonide can effectively improve the macular edema caused by retinal vein occlusion.%目的:评估玻璃体腔内注射曲安奈德(triamcinolone acetonide,TA)治疗视网膜静脉阻塞(retinal vein occlusion,RVO)引起的黄斑水肿的长期安全性与有效性.方法:患者17例17眼出现视网膜静脉阻塞引起的黄斑水肿,接受玻璃体腔内注射2mg TA,随访1a,监测患者视力、黄斑厚度.结果:随访发现,15眼(88%)视力得到明显改善,从术前0.114±0.068增加到术后的0.184±0.094,差异有统计学意义(P＜0.05),而中央黄斑区的厚度从术前的514.0±67.4μm减少到术后的442.0±61.5μm,差异有统计学意义(P<0.05).术后6例患者出现短期眼压升高,并无并发性白内障,玻璃体出血,视网膜脱离以及眼内炎的发生.结论:玻璃体腔内注射TA能长期有效减缓RVO引起的黄斑水肿.