吡咯里西啶生物碱性肝损伤研究进展

摘要

Abuse of traditional Chinese medicine is the most common risk factor of drug-induced liver injury in China. As the morbidity of hepatic sinusoidal obstruction syndrome caused by"Tusanqi" is increasing gradually, the hepatotoxicity of pyrrolizidine alkaloids as the main component of"Tusanqi" has been paid more attention. In the current studies, the mechanism, clinical manifestation, natural course and therapy of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids have been explored and demonstrated. Furthermore, pyrrolizidine alkaloids shows its role as a liver tumorigenesis which is mediated by one of a common metabolic activation pathways via the metabolic product-DNA complex.%在我国,传统中药的不合理使用是药物性肝损伤最常见的原因.近年来,土三七等传统中药所致肝窦阻塞综合征(hepatic sinusoidal obstruction syndrome,HSOS)的发病率逐渐升高,其主要药效成分吡咯里西啶生物碱(pyrrolizidine alkaloids,PAs)的肝毒性也逐渐被重视.国内外诸多研究进一步明确了PAs对肝脏的损伤作用,尤其对PAs所致HSOS的作用机制、临床表现、自然病程及治疗进行深入阐述,同时亦发现PAs除可引起HSOS外,还可通过其二级代谢产物与DNA所形成络合物激活代谢活化机制,进而诱导肝癌的发生.