CBS催化合成β-受体激动剂关键中间体——手性α-卤代仲醇

摘要

A series of chiral α-halo secondary alcohols, the key intermediates of D-receptor agonists, was obtained via asymmetric reduction of α-halo-acetophenone derivatives catalyzed by Corey-Bakshi-Shibata (CBS) catalyst (R/S)-α,ct-diphenyl-2-pyrrolidinemethanol and their yield and optical purity were better.%用CBS催化剂中的R/S-α,α-二苯基脯氨醇为催化剂不对称还原α-卤代苯乙酮衍生物,得到系列手性α-卤代仲醇--β-受体激动剂关键中间体,反应具有较好的收率,产物光学纯度高.