杭州市治疗精神障碍基本药物使用状况评价

摘要

目的了解杭州地区2009版和2012版治疗精神障碍基本药物使用状况及变化趋势，评价基本药物目录的合理性。方法采用世界卫生组织推荐的限定日剂量(DDD)方法，对杭州地区26家医院2010年-2012年治疗精神障碍基本药物的使用状况进行统计分析。结果销售金额逐年增长，2009版基药权重小，趋势下降；2012版新增基药权重大，趋势上升。用药频度(DDDs)整体趋势向上，构成比与2010年比较，2009版基药“先升后降”，2012版新增基药“先降后升”。2009版基药皆为经典老药，新一代药物日均费用（DDC）相对较高。结论治疗精神障碍基本药物销售金额和用药频度整体呈上升趋势，2012版新增基药已占临床治疗用药的主导地位。2012版基药弥补了2009版基药“数量少，品种老”的不足，渐趋合理，但仍需定期补充完善。%Objective:To evaluate the rationality of the Essential Drug List (EDL) based on the use and changes of essential antipsychotics in EDL Edition 2009 and Edition 2012. Methods:The article applied statistical analysis on the use of antipsychotic essential drugs in 26 hospitals of Hangzhou from 2010 to 2012, with reference to defined daily dose (DDD) recommended by WHO. Results:The total consumption of essential drugs increased year by year, but essential drugs in EDL Edition 2009 demonstrated smaller weight and downward trend while newly added essential drugs in EDL Edition 2012 demonstrated larger weight and upward trend. The overall DDDs increased. With the constituent ratio of essential drugs in 2010, the ratio of essential drugs in EDL Edition 2009 increased in 2011 then decreased in 2012, while the ratio of newly added essential drugs in EDL Edition 2012 decreased in 2011 then increased in 2012. Compared with classic essential drugs in EDL Edition 2009, new-generation drugs had higher daily drug costs (DDC). Conclusion:The overall consumption and DDDs of antipsychotic essential drugs are on the rise. Newly added essential drugs in EDL Edition 2012 are taking the lead in clinical medication. Newly added essential drugs in EDL Edition 2012 are supplementary to essential drugs in EDL Edition 2009 by adding new varieties and specifications. EDL Edition 2012 demonstrates greater rationality, but still needs regular supplement and improvement.