Objective To explore and investigate the relative risks of sharp instrument injuries among medi -cal staff , and discuss the countermeasures .Methods Information and occurrence situation of sharp instrument inju -ries among medical staff were collected by prospective surveillance .Results From Jan 2012 to Dec 2012, the num-ber of medical staff with the occurrence occupational exposure was 130, while 121 of them were hurt by sharp instru-mental (93.08%), 8 were contacted on their skin and mucosa (6.15%), 1 was punctured on the end of in vitro stump (0.77%) .Medical-surgical unit and transfusion hall of out -patient were major occurrence place of sharp instrument injuries;puncture , injection and blood collection were common steps .The exposure source of hepatitis B ranked the first (33.06%);the number of first -level exposure was 7 (5.79%), the second-level exposure was 114 (94.21%) .The tracking survey on those medical staff who were hurt by sharp instrument showed that no one got hematogenous spread disease .Conclusion Sharp instrument injury is a common exposure in medical practice .Com-plying with the standardized operation , paying attention to the self -protection are efficient ways to decrease occur-rence rate of occupational infection .%目的：调查医护人员医疗锐器损伤的相关因素，探讨有效的职业防护管理措施。方法采用前瞻性研究方法，监测医务人员医疗锐器损伤发生情况。结果2012年1-12月医务人员发生职业暴露共130人其中发生医疗锐器损伤121名、占93．08％，皮肤黏膜接触8人、占6．15％，离体残肢端刺伤1人、占0．77％；内外科病房和门诊输液厅是锐器伤主要发生场所；各种诊疗穿刺和注射、采血操作是常见的锐器伤环节；暴露源为乙型肝炎者占首位为33．06％；一级暴露7人、占5．79％，二级暴露114人、占94．21％。所有医疗锐器损伤的医务人员经追踪观察，无一人发生血源传播性疾病。结论医疗锐器伤是医疗操作中常见的职业暴露，遵守操作规程，重视自身的防护是降低职业性感染的有效方法。
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