SIRT3与细胞代谢及心血管疾病的相关性

摘要

Protein deacetylases play an extremely crucial role in cellular biological processes and have been cate-gorized into four families (HDACⅠ, HDACⅡ, HDACⅢ and HDACⅣ) in human. Of them, HDACⅢ, also known as the Sir2 (Silent information regulator 2) family, contains seven members, SIRT1−7, each exhibiting different cellular localiza-tion and biological function. As a major mitochondrial deacetylase, SIRT3 not only modulates cellular metabol-ism, but also plays important roles in apoptosis, tumor growth, aging and a number of other diseases. In this review, we summarize recent findings related to SIRT3 with an emphasis on its biological functions in regulating cell meta-bolism and its possible roles in cardiovascular diseases.%蛋白去乙酰化酶在细胞生理过程中发挥着极为重要的作用。人蛋白去乙酰化酶包括HDACⅠ、HDACⅡ、HDACⅢ和HDACⅣ4个家族。其中第Ⅲ类即Sir2(Silent information regulator 2)家族包括7个成员——SIRT1~SIRT7，每个成员都具有不同的细胞定位，并且发挥不同的生物学功能。作为主要定位于线粒体的组蛋白去乙酰化酶，SIRT3不仅调节细胞的能量代谢，并在细胞凋亡、肿瘤生长和一些疾病中发挥作用。文章综述了SIRT3在细胞代谢中的生物学功能以及其在心血管疾病中的研究进展。