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【6h】Localized correlation analysis and genetic association with cardiovascular disease.

机译局部相关性分析和遗传相关性与心血管疾病。

【摘要】Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven datasets relevant to cardiovascular disease studies. The genomes of samples were separated into 20Mb windows and correlation tests were performed locally in these windows. The localized Pearson correlation test found chr3:115Mb-135Mb was tightly connected by significantly high proportion of highly correlated pairs ( P value = 0.0266 with Z-test). LSAMP, GATA2, MBD4, and other genes in the region were considered associated with cardiovascular disease because they were involved in highly correlated pairs. Furthermore, these genes were also associated with cardiovascular disease by having significantly high SNP odds ratios (P value < 0.1) between patients and controls in an independent Duke University Medical Center database. In addition, a permutation test was performed to demonstrate that chr3:115Mb-135Mb might underlie the regulation of cardiovascular disease. Finally, the localized Pearson correlation test also found some other regions that could be associated with cardiovascular disease.

【摘要机译】基因表达的变化是动脉粥样硬化的潜在危险因素,这是心血管疾病的最常见形式之一。我们在与心血管疾病研究相关的七个数据集中对372个人进行了局部Pearson相关性测试。将样品的基因组分成20Mb窗口,并在这些窗口中局部进行相关测试。本地化的Pearson相关性测试发现chr3:115Mb-135Mb通过高比例的高度相关对紧密相连(Z检验的P值= 0.0266)。 LSAMP,GATA2,MBD4和该区域的其他基因被认为与心血管疾病有关,因为它们与高度相关的基因对相关。此外,在独立的杜克大学医学中心数据库中,患者与对照之间的SNP比值比极高(P值<0.1),这些基因也与心血管疾病相关。另外,进行了置换测试以证明chr3:115Mb-135Mb可能是心血管疾病的调控基础。最后,本地化的Pearson相关性测试还发现了其他可能与心血管疾病有关的区域。

【作者】Ou, Chern-Han.;

【作者单位】Duke University.;

【年(卷),期】2010(),

【年度】2010

【页码】110 p.

【总页数】110

【原文格式】PDF

【正文语种】eng

【中图分类】;

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