左旋紫草素转化工艺

摘要

Objective To investigate the optimal condition for transforming alkanna tinctoria pigment into shikonin. Methods Transformation rate of shikonin served as index. Transformation temperature, time, ratio of 2% NaOH to alkanna tinctoria pigment (v/w) was optimized. Results With ratio of 2% NaOH to alkanna tinctoria pigment being 4.5 mL·mg-1, temperature 35℃ and the reaction time 4 h, the transformation rate reached the highest, and the average transformation rate was 64.86%. Conclusion This method is easy and simple, and suitable for industrialized production.%目的 研究紫草总色素转化为左旋紫草素的最佳工艺条件. 方法 采用L9(34)正交实验法,以左旋紫草素转化率为指标,优选转化温度、转化时间、2%氢氧化钠的体积与紫草总色素的质量比. 结果 温度35 ℃,转化时间4 h,2%氢氧化钠的体积与紫草总色素的质量比例为4.5 mL·mg-1时,紫草素转化率最高,平均转化率为64.86%. 结论 该优选工艺方便简便,经济环保,适合工业化生产.