Objective: To observe the therapeutic effectiveness and toxicity of advanced gastric cancer treated with docetaxel, cisplatin and fluorouracil. Method: Docetaxel 75mg/m2, iv drip, dl; cisplatin 75mg/m2, iv drip, d1-d2; fluorouracil 2400mg/m2, persistent iv drip for 48h. 21 days for a phase, 2 phases for using continuously. Result: The treatment effect of 30 cases of patients could be assessed, the total effective rate was 86.7％ (26/30) , the effective rate for initial treatment was 88％, the effective rate for retreatment was 75 ％; toxicity primarily include bone marrow suppression, baldness, gastrointestinal reaction,diarrhea, etc, which could be tolerated. Conclusion: It could obtain satisfactory results for treatment of advanced gastric cancer with docetaxel, cisplatin and fluorouracil, it is a good chemotherapy combination.%目的:观察多西他赛与顺铂联合氟尿嘧啶(DCF方案)治疗进展期胃癌的疗效及毒副反应.方法:多西他赛75mg/m2,静脉滴注d1,顺铂75mg/m2分2d静脉滴注d1-d2,氟尿嘧啶2400mg/m2持续静点48h,每21d为一周期,连续2个周期.结果:30例患者均可评价疗效,总有效率为86.7%(26/30),其中初治有效率为88%,复治有效率75%,毒副反应主要是骨髓抑制、脱发、胃肠道反应、腹泻等,均可以耐受.结论:多西他赛联合顺铂、氟尿嘧啶治疗进展期胃癌可以获得满意疗效,是一个较好的化疗方案.
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