盐酸曲马多联合黄体酮治疗急性肾绞痛效果研究

摘要

Objective:To explore the effect of intramuscular tramadol hydrochloride combined with pro-gesterone on acute renal colic .Method:86 cases of acute renal colic were randomly divided into observation group (44 cases) and control group(42 cases).The observation group was given 100mg tramadol intravenous drip combined with 40mg progesterone, the control group was given 100mg meperidine hydrochloride injec-tion with 0.5mg atropine sulfate.Visual analog scale(VAS)was used to record patients pain degree and ana-lyze the onset time and adverse effects before and after drug delivery 15min, 30min, 1h, 4h respectively. Result:There were no significant differences on effective rate and drug onset time between the two groups ( P>0.05) .The VAS scores of observation group after drug delivery from 15min to 4 hours were lower than the control group(P<0.05), rates of adverse drug reactions such as dizziness , xerostomia, uroschesis in observa-tion group were lower than control group (P<0.05).Meanwhile, progesterone intramuscular injection were given to observe group with 30mg/QD in three days, Kidney stones were excluded of 12 cases which showed significant difference with the control group .Conclusion: Intramuscular tramadol hydrochloride combined with progesterone on acute renal colic shows significant effect , which would be used as the emergency medi-cine on acute renal colic .%目的：观察肌肉注射盐酸曲马多联合肌肉注射黄体酮治疗急性肾绞痛的临床效果。方法：86例确诊为急性肾绞痛患者随机分为观察组和对照组，观察组（44例）给予肌肉注射盐酸曲马多100mg同时肌肉注射黄体酮40mg，对照组（42例）给予肌肉注射盐酸哌替啶100mg及硫酸阿托品0．5mg。给药前、后15min、30min、1h、4h对患者疼痛采用视觉模拟评分（ VAS）评价其疗效，并观察其起效时间和不良反应。结果：观察组止痛总有效率为90．91％，对照组总有效率为90．48％，两组止痛疗效比较无统计学差异（P＞0．05）；两组药物起效时间比较无统计学差异（ P＞0．05）。给药后15min 后至4h，观察组VAS评分均低于对照组（ P＜0．05）；观察组患者发生眩晕、口干、尿潴留不良反应的比例明显低于对照组（ P＜0．05）。连续3d对观察组给予肌肉注射黄体酮40mg／QD后，12例患者出现排石，与对照组相比差别有显著性（ P＜0．05）。结论：肌肉注射盐酸曲马多联合肌肉注射黄体酮对急性肾绞痛有明显的镇痛作用，可作为治疗急性肾绞痛的急诊用药。