Objective:To investigate the non-invasive hemodynamic effection during the general anes-thesia given dexmedetomidine and propofol under the same anesthesia depth .Method:64 patients ,ASAⅠ~Ⅱlevel ,under the elective subtotal thyroidectomy , were randomly divided into two groups:dexmedetomi-dine group (group D,n=32) and propofol group ( group C,n=32), Atropine 0.5mg, imidazole 4mg, Dexmedetomidine [ 1.0μg/kg at induction of anesthesia with 10min , then 0.5 μg · kg-1 · h-1 for mainte-nance of anesthesia] fentanyl 0.25mg, rocuronium 50mg were given to intubate, while Propofol [100mg at induction of anesthesia ,then set to target the mass concentration of 4 ~5mg/L for maintenance of anesthe-sia]were given to the group C, and the others were the same.During the intraoperative,both of the groups were used the cis-atracurium and remifentanil to maintain of anesthesia , used the Bioz .com to monitor the noninvasive hemodynamic reaction and used the BIS to maintain the same anesthesia depth 40~50 .Heart rate (HR), mean arterial pressure(MAP), cardiac index(CI), stroke volume index (SI), systemic vascu-lar resistance ( SVR) were recorded before the operation ( T1 ) , before the intubation ( T2 ) , after the intuba-tion (T3), the beginning of operation (T4), 10min of the operation(T5), before the extubation(T6),after the extubation(T7).Result:In the entire surgical procedure, under the same level of the BIS, two groups of patients in the use of remifentanil dose per unit time difference has statistical significance ,dose was signifi-cantly lower in group D.For HR, MAP, SI, SVR,with different anesthetic methods and phase , the change tendency is different,except the HR, group D is more steady (P <0.05).For CI,with different anesthesia phase, change tendency is not different .Conclusion:Dexmedetomidine [1.0μg/kg at induction of anesthe-sia with 10min,then 0.5μg· kg-1 · h-1 for maintenance of anesthesia ] have sedation analgesia effect , inhi-bition of stress reaction , and is more stabile than propofol for hemodynamic effection .%目的：评价全麻过程中右美托咪定和丙泊酚在同等麻醉深度下无创血流动力学影响。方法：择期行甲状腺大部切除术患者64例，ASA分级或Ⅱ级。采用随机数据表法，分成两组（ n＝32）：右美托咪定组（ D组）和丙泊酚组（ C组）。 D组入手术室后给以阿托品0．5mg，咪唑4mg，右美托咪定1．0μg／kg负荷量10min内注完，芬太尼0．25mg，罗库溴铵50mg诱导插管，后右美托咪定0．5μg· kg－1· h－1麻醉维持。 C组给予丙泊酚100mg，其它相同诱导插管，后丙泊酚以靶质量浓度设定为4～5mg／L维持麻醉。两组术中均用顺阿曲库铵，瑞芬太尼麻醉维持，用Bioz．com 系统监测无创血流动力学， BIS40～50。于入室（ T1），插管前（ T2）、后（ T3），手术开始（ T4），10min（ T5）、拔管前（ T6）、后（ T7）记录患者的心率（ HR）、平均动脉压（ MAP ）、心脏指数（ CI ）、每搏指数（ SI ）、外周循环阻力（ SVR ）。结果：在同等BIS水平，两组患者瑞芬太尼的剂量D组低于C组。 HR、MAP、SI、SVR不同麻醉方法不同麻醉时相变化趋势不同，除HR外，D组均比C组稳定（ P＜0．05），CI不同麻醉时相变化趋势相同。结论：右美托咪定负荷量1．0μg／kg，0．5μg· kg－1· h－1用于全麻诱导和维持，具有镇静镇痛作用，抑制应激反应，血流动力学较稳定。
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