癫痫儿童智能和适应能力分析及抗癫痫药物治疗的影响

摘要

目的：分析癫痫儿童与正常儿童智能和适应能力差别，观察抗癫痫药物治疗前后对智能和适应能力的影响。方法：选择2013年1月至2013年12月我院50例9～16岁癫痫患儿，随机分为两组，分别给予奥卡西平（ OXC）和卡马西平（ CBZ）治疗，于治疗前和治疗12个月后测试智能和适应能力，并选择同期性别、年龄、父母文化程度与之相匹配的健康检查正常儿童50例设为正常组，采用相同的方法测试智能和适应能力。结果：癫痫组和正常组WISC－R评分中语言IQ、操作IQ及总IQ评分差异无显著性（ P＞0．05）；单项评分中，算术、常识、理解、图片排列、类同、拼图评分差异无显著性（ P＞0．05）；但癫痫儿童背数、译码、填缺评分明显低于正常组（P＜0．05）。癫痫组患儿P300潜伏期异常率为28．0％，高于正常组，SLPS正常率为70．0％，低于正常组（ P＜0．05）。服用抗癫痫药物12个月，CBZ组患儿背数评分较治疗前略有降低，两组语言IQ、操作IQ、总IQ评分及各单项评分较治疗前均略有上升，差异均无显著性（ P＞0．05）；治疗前后两组患儿适应能力比较差异无显著性（ P＞0．05）。结论：智力正常的癫痫患儿伴有不同程度的适应能力和智能低下，常规抗癫痫药物及新型抗癫痫药物均对智能和适应能力无明显影响，癫痫患儿一旦确诊及时治疗避免疾病造成更严重的智能损害。%Objective:To analyze the difference of intelligence of epileptic children and normal children and the ability to adapt, observe the intelligence and ability to adapt to the effect before and after treatment with antiepileptic drugs.Method: 50 cases of 9~16 years old children with epilepsy in our hospital from January 2013 to December 2013, were randomly divided into two groups, respectively given oxcarbazepine ( OXC) and C Masi Bing ( CBZ) treatment, before treatment and after 12 months of treatment, Tested of in-telligent and adaptive capacity, and chose the same gender, age, educational level of parents and to match the health examination of50 normal children served as normal group, the same test method using intelligent and adaptive ability.Result:The scores of WISC-R in epilepsy group and normal group in language IQ , op-eration IQ and total IQ score had no significant difference ( P<0.05);individual scores, arithmetic, common sense, understanding , picture arrangement, similar to puzzle scores, There's significant difference ( P>0. 05);but the number of epileptic children back, decoding, fill in the missing score was significantly lower than those of normal group (P<0.05).The abnormal rate of P300 in children with epilepsy group latency is 28%, higher than the normal group, the normal rate of SLPS was 70%, which was lower than that of normal group ( P<0.05 ) .Taking antiepileptic drugs for 12 months, group CBZ patients back number rating de-creased slightly than before treatment, two groups of language IQ, operation IQ, total IQ score and each item score than before treatment were increased slightly , there was no significant difference (P>0.05 ); before and after treatment, the difference two groups of children with the ability to adapt has of no significant ( P>0. 05 ) .Conclusion:Children with epilepsy has normal intelligence is different degree of adaptability and men -tal retardation,antiepileptic drugs and new antiepileptic drugs on intelligence and adaptive ability in children with epilepsy had no obvious effect, once the diagnosis and timely treatment to avoid diseases cause more se-rious harm intelligent loss.