Objective To study of the influence on cognitive function in children with benign childhood epilepsy with centro-temporal spikes(BECTS) monotherapy with levetiracetam(LEV) or lamotrigine(LTG). Method 52 cases with BECTS,intelligence test and event related potentials(ERPs)P300 were examined respectively before treatment and after six months of treatment,and then compared the differences of the results. Results ①Compared with before treatment group, ERPs the differences of P300 latency and intelligence test were statistically significant then after treatment group of LEV (P<0.05).②Compared with before treatment, the differences of ERPs P300 latency and intelligence test were statistically significant then after treatment group of LTG (P<0.05).③After monotherapy of LEV and LTG, P300 latency and intelligence test, There were no statistical difference(P>0.05).Conclusion LEV and LTG improved intelligence level of children through supressing epileptiform discharges effectively,there was no difference between the influence of the two drugs on intelligence.%目的 探讨左乙拉西坦(LEV)与拉莫三嗪(LTG)单药治疗伴中央颞区棘波的儿童良性癫痫(BECTS)患儿对认知功能的影响.方法 选取52例BECTS患儿,治疗前及治疗6个月后分别进行智力测试及事件相关电位P300检查,并比较二者结果之间的差异.结果 ①LEV治疗后P300潜伏期、智力测试与治疗前比较,t=2.327、-6.194,差异有统计学意义(P<0.05);②LTG治疗后P300潜伏期、智力测试与治疗前比较,t=4.391、-10.445,差异有统计学意义(P<0.05);③LEV与LTG单药治疗后P300潜伏期t=1.392,智力测试t=-1.387,差异无统计学意义(P>0.05).结论 LEV与LTG均通过有效抑制癫痫样放电,进而改善患儿智力水平,两药之间对比对智力影响差异无统计学意义.
展开▼
