前列地尔联合丹红对早期糖尿病肾病患者肾功能及血清炎症因子水平的影响

摘要

Objective: To investigate the effects of alprostadil combined with Danhong on the renal function and serum levels of inflammatory factors in patients with early diabetic nephropathy.Methods:Totally 80 patients with early diabetic nephropathy were selected and randomly divided into observation group and con-trol group, with 40 patients in each group. Both groups were given conventional therapies, and the control group used Danhong injection ( TCM) additionally, while the observation group used alprostadil injection in addition to those of the control group. The levels of blood urea nitrogen ( BUN) , blood creatinine ( SCr) ,β2 microglobulin (β2-MG), 24h quantitative test for urinary protein (24h Upro), urinary albumin excretory rate ( UAER) , and serum interleukin-6 ( IL-6) , interleukin-18 ( IL-18) , tumor necrosis factor -α( TNF-α) , and hypersensitive C reactive protein ( hs-CRP ) before and after treatment were compared between the two groups. Results:Before treatment, the two groups had insignificantly different levels of BUN, SCr, 24h Upro,β2-MG, UAER and serum IL-6,IL-18,TNF-α,and hs-CRP ( P>0.05); after treatment, both groups had significantly decreased levels of BUN, SCr, 24 h Upro,β2-MG, UAER and serum IL-6, IL-18, TNF-α, and hs-CRP , but the observation group had significantly greater decreasing extents than the control group ( P<0.05) . Conclusion:Alprostadil combined with Danhong can effectively improve the renal function and de-crease the levels of inflammatory factors in patients with early diabetic nephropathy, and is highly effective and safe.%目的：：探讨前列地尔联合丹红对早期糖尿病肾病患者肾功能及血清炎症因子水平的影响，寻找理想的治疗方式。方法：选择80例早期糖尿病肾病患者，随机分为观察组和对照组各40例，两组患者均给予常规治疗，对照组加用丹红注射液，观察组在对照组基础上加用前列地尔注射液，比较两组患者治疗前后血尿素氮(BUN)、血肌酐(SCr)、β2微球蛋白(β2－MG)、24h尿蛋白定量(24h Upro)、尿白蛋白排泄率(UAER)，以及血清白细胞介素－6(IL－6)、白细胞介素－18(IL－18)、肿瘤坏死因子－α( TNF－α)、超敏C反应蛋白( hs－CRP )。结果：治疗前，两组患者BUN、SCr、24h Upro、β2－MG、UAER及血清IL－6、IL－18、TNF－α、hs－CRP 水平相似相似，差异无统计学意义(P>0.05)；治疗后，两组患者BUN、SCr、24h Upro、β2－MG、UAER及血清IL－6、IL－18、TNF－α、hs－CRP 水平较本组治疗前均下降，但是观察组下降幅度更显著，差异有统计学意义( P<0.05)。结论：前列地尔联合丹红可以有效改善早期糖尿病肾病患者肾功能，降低炎性因子水平，临床疗效显著，安全性高。