阿罗洛尔治疗高血压合并焦虑抑郁的临床研究

摘要

目的:观察阿罗洛尔治疗原发性高血压合并焦虑、抑郁患者的临床疗效.方法:选取2016年2月至2017年2月于承德市中心医院高血压门诊诊断为1～2级高血压患者,同时经焦虑、抑郁自评量表评分诊断为焦虑抑郁状态的患者67例,随机分为实验组及对照组,对照组患者给予常规抗高血压药物马来酸依那普利10mg每日一次治疗,实验组患者给予盐酸阿罗洛尔10mg每日一次,治疗4周后评定两组患者治疗前后血压下降程度及焦虑自评量表(SAS)、抑郁自评量表(SDS)得分变化情况.结果:两组患者血压水平均较治疗前有下降,差异具有统计学意义(P<0.01),两组间血压下降水平比较差异无统计学意义(P>0.05),实验组焦虑抑郁症状改善,与对照组比较差异具有统计学意义(P<0.01).实验组治疗后心率下降,与对照组相比具有统计学意(P<0.01).结论:高血压合并焦虑抑郁患者经盐酸阿罗洛尔治疗后,可有效降低患者血压水平,同时改善患者的焦虑、抑郁状态.%Objective:To investigate the clinical efficacy of Arotinolol treatment of patients with hyper-tension associated with anxiety and depression. Methods:67 cases of patients with 1-2 stage hypertension as-sociated with anxiety and depression disorder being evaluated by SAS and SDS from Chengde Central Hospital Hypertension clinic were divided into experimental group and control group from February 2016 to April 2017. The control group were treated with Enalapril 10mg once a day and the experimental group were treated with Arotinolol 10mg once a day for 4 weeks. Two groups were evaluated with Depression Rating Scale ( SAS) and Self-Rating Anxiety Scale ( SDS) and the blood pressure were measured before and after treatment. Results:The effects of hypertension in two groups showed significant difference ( P <0.01) than those before treatment. There was no significant difference in the level of blood pressure drops between the two groups ( p>0.05) . The score of SAS and SDS were lower ( P<0.01) in the experimental group showed significant difference ( P<0. 01) compared with the control group. The heart rate of the experimental group decreased significantly after treatment compared with that of the control group (p<0.01). Conclusion:Arotinolol can effectively reduce the blood pressure and score of Depression Rating Scale ( SAS) and Self-Rating Anxiety Scale ( SDS).