大剂量泮托拉唑治疗急性非静脉曲张性上消化道出血

摘要

目的：探讨急性非静脉曲张性上消化道出血采用大剂量泮托拉唑持续静脉泵入治疗的临床效果。方法选取2014年3月至2016年3月诊治的57例急性非静脉曲张性上消化道出血患者，随机分为观察组和常规组两组，28例观察组采用大剂量泮托拉唑持续静脉泵入治疗，29例常规组采用常规剂量泮托拉唑治疗，比较两组患者的止血效果与预后情况。结果相对于常规组观，观察组的住院天数和输血量均更少，两组间比较差异有统计学意义（P＜0.05）。而在治疗有效率方面，观察组高于常规组（89.3％vs.79.3％），组间差异有统计学意义（P＜0.05）。结论大剂量泮托拉唑持续静脉泵入是治疗急性非静脉曲张性上消化道出血的有效方法，可明显提高疗效，缩短住院时间。%Objective To investigate the clinical effect of different doses of pantoprazole in treatment of nonvariceal upper gas-trointestinal bleeding(ANVUGIB). Methods We collected the data of 57 patients with ANVUGIB admitted in our hospital from March 2014 to March 2016. The 57 patients were divided into two groups:observation group and regular group. Patients in the observation group were given continuous pumping of 8 milligrams of pantoprazole per minute for 72 hours after intravenous injection of 80 mg of pantopra-zole, patients in the regular group were given intravenous instillation of 40 mg of pantoprazole every 12 hours. Then we compared the clinical effect between two groups. Results Observation group total effective rate was 89.3%, conventional group total effective rate was 79.3%, two groups compare difference was statistically significant(P<0.05). The average hospitalization days of patients in the observa-tion group and the regular group was (7.9±2.7)days and (11.8±3.9)days, respectively, there was a statistical significant difference (P<0.05). The blood transfusion volumes of patients in the observation group was less than that in the regular group. Conclusion Con-tinuous pumping of 8 milligrams of pantoprazole per minute after intravenous injection of 80 mg of pantoprazole has better hemostatic ef-fect, shorter hospitalization time, and less blood transfusion volume in treatment of nonvariceal upper gastrointestinal bleeding, so it is worthy of clinical promotion.