Objective To appraise the early changes and clinical significances of C-reactive protein (CRP)and high sensitive C-reactive protein (hsCRP) in septicemia of newborn. Methods The densities of CRP and hsCRP were measured in 96 newborn patients with septicemia (septicaemia group) and 93 newborn patients with other diseases (control group) from August 2009 to January 2011, then the changes of the CRP and hsCRP positive rate were observed in two groups. Results The CRP positive rate was 94.79％ in septicaemia group, and 8.60％ in control group,with the significant difference between them (P＜0.05); the hsCRP positive rate was 97.92％ in septicaemia group, and 5.38％ in control group, with the significant difference between them (P＜0.05). However, the densities of CRP and hsCRP were federatively measured can improve the successful rate. Conclusion The early changes of CRP and hsCRP were significant and they conduce to early clinical diagnosis in septicemia of newborn.%目的 探讨C反应蛋白(CRP)和高敏C反应蛋白(hsCRP)在新生儿败血症早期的改变及临床意义.方法 对本院在2009年8月至2011年1月收治的96例新生儿败血症患者(败血症组)以及其他疾病的93例新生儿患者(对照组)进行血清CRP和hsCRP的浓度测定,观察比较两组患者的CRP和hsCRP阳性率变化.结果 败血症组和对照组之间的CRP阳性率分别为94.79%和8.60%,二者之间差异有统计学意义;败血症组和对照组之间的hsCRP阳性率分别为97.92%和5.38%,二者之间差异有统计学意义.结论 CRP和hsCRP在新生儿败血症早期有显著的改变并有助于新生儿败血症的临床早期诊断.
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