缺血性脑血管病患者颈动脉病变与糖代谢的相关性分析

摘要

目的 探讨缺血性脑血管病患者颈动脉病变与糖代谢的相关性危险因素.方法 从我院神经内科就诊经颈动脉彩超发现颈动脉斑块的缺血性脑血管病患者中选择血胆固醇及甘油三酯稳定在无明显差异范围内的187例患者进行观察.按检查结果及病史分为糖耐量正常组(NGT组,n=47),合并糖耐量减低进行比较组(IGT组,n=68)及合并糖尿病组(T2DM组,n=72).收集患者性别、年龄、合并症及检查结果等各项资料并对比.结果 T2DM组、IGT组的病例数明显高于NGT组,差异有统计学意义.IGT组及T2DM组中的吸烟人数比例、高血压人数比例及BMI、WHR均高于NGT组,差异有统计学意义,空腹血糖、餐后血糖、C反应蛋白方面组间差异有统计学意义,IGT组的上述指标明显高于NGT组且明显低于T2DM组,且上述指标与颈动脉粥样斑块积分呈正相关.结论 糖代谢异常为颈动脉病变的独立危险因素,高血压、吸烟、CRP、BMI、WHR同样为颈动脉病变的危险因素.%Objective To investigate the correlation between carotid artery disease and glucose metabolism in patients with ischemic cerebrovascular disease. Methods one htundred and eighty-seven patients with carotid artery plaque, in which blood cholesterol and triglycerides showed no statistically significant difference, were selected and observed. According to test results and medical history, the patients were divided into three groups: normal glucose tolerance group (NGT group, n=47), combined impaired glucose tolerance group (IGT group, n=68) and the diabetes group (T2DM group, n=72). The gender, age, complications, and test results were compared between the three groups. Results The number of cases was significantly higher in T2DM group and IGT group man NGT group. The proportion of smokers, the proportion of high blood pressure, BMI and WHR were significantly higher in IGT group and T2DM group than NGT group. The levels of fasting glucose, postprandial blood glucose, C-reaca've protein showed statistically significant difference between me three groups, which was the highest in T2DM group, then IGT group and lowest in NGT group, showing a positive correlation with the carotid artery plaque. Conclusion Abnormal glucose metabolism is the independent risk factors of carotid artery disease, as well as hypertension, smoking, CRP, BMI, and WHR.