Objective To study the variation of early p-amyloid precursor protein and various inflammatory factors in patients with diffuse axonal injury (DAI). Methods Thirty patients with diffuse axonal injury in our hospital from January 2008 to May 2011 were enrolled in this study. The contents of β-amyloid precursor protein in Cere-bro-Spinal Fluid (CSF), IL-1β, IL-6, IL-8, TNF-α and CRP in serum at 1 h, 6 h, 12 h, 24 h, 48 h, 72 h after trauma were detected and compared in all the patients. Results The contents of β-amyloid precursor protein in CSF, and IL-1β,IL-6, IL-8, TNF-α and CRP in serum showed an increasing trend in all the patients. The IL~1β content in serum reached the peak at 6 h, then began to decrease at 48 h. The β-amyloid precursor protein content in CSF and the CRP content in serum reached the peak at 24 h. Then the β-amyloid precursor protein content kept at the peak, while the serum CRP began to decrease, The levels of IL-6, IL-8 and TNF-α in serum reached the peak at 48 h. TNF-α began to decrease at 72 h, but IL-6 and IL-8 kept at the higher level, and the change range of the severe patients were significantly larger than the moderate and mild patients (P<0.05). Conclusion The contents of β-amyloid precursor protein in CSF, serum IL-1β, IL-6, IL-8, TNF-α, CRP of patients with diffuse axonal injury change regularly, which plays constructive roles for investigating the severity, development and prognosis of DAI.%目的 探讨弥漫性轴索损伤患者伤后早期β淀粉样前体蛋白及其多项炎性因子的变化规律.方法 选取30例弥漫性轴索损伤患者为研究对象,检测其伤后1h、6h、12h、24h、48h及72h的脑脊液中β淀粉样前体蛋白水平及血清中IL-1β、IL-6、IL-8、TNF-α、CRP水平并进行比较.结果 所有患者的脑脊液β淀粉样前体蛋白水平及血清IL-1β、IL-6、IL-8、TNF-α、CRP水平均呈现升高趋势,血清IL-1β含量在伤后6h达到峰值,48 h开始下降,脑脊液β淀粉样前体蛋白及血清CRP含量在伤后24h达到峰值,β淀粉样前体蛋白水平维持在峰值水平,血清CRP开始下降,血清IL-6、IL-8、TNF-α含量则于伤后48 h达峰值,伤后72 h血清TNF-α含量开始下降,IL-6、IL-8含量持续在较高的水平,且重度患者变化幅度要大于轻度及中度患者(P均＜0.05),差异有统计学意义.结论 弥漫性轴索损伤患者早期β淀粉样前体蛋白及血清IL-1β、IL-6、IL-8、TNF-α、CRP水平均呈现一定的变化规律,对于了解疾病的严重程度及发展转归有着积极作用.
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