早期应用乌司他丁对中重度烧伤患者的脏器保护作用

摘要

目的 探讨早期应用乌司他丁对中重度烧伤患者的脏器保护的方法和疗效,为临床治疗提供参考.方法 将2008年1月至2011年1月收治入院的80例中重度烧伤患者采用随机抽取法分为两组,对照组40例,行烧伤常规治疗；实验组40例,在常规治疗的基础上加用乌司他丁.随访1～2个月,检测两组患者治疗前后的血常规、肝功能(丙氨酸转氨酶)、肾功能(血尿素氮、血肌酐)变化.结果 随访期间两组内相比,治疗后患者血常规、肝肾功能变化均优于治疗前,差异有统计学意义(P＜0.05)；两组间相比,治疗后实验组患者的血常规、肝肾功能变化均优于对照组,差异无统计学意义(P＞0.05).结论 早期应用乌司他丁治疗中重度烧伤患者可使疗效得到显著提高,对心,肝,肾等重要器官起到积极的保护作用,有利于提高患者的生存质量,且安全性高,值得在临床七推广.%Objective To investigate the early use of UTI in patients with severe burns, organ protection method and effect, to provide guidance for clinical treatment. Methods A retrospective analysis of our hospital in January 2008 to January 2011 of 80 cases admitted to hospital in severe burn patients. Using randomly divided into 2 groups, control group of 40 patients, and burn conventional treatment. Experimental group of 40 patients in the conventional treatment based on the use of UTI. Follow-up in January-February, two groups of patients before and after testing the blood, liver function (alanine aminotransferase), renal function (blood urea nitrogen, serum creatinine) changes. Results During follow-up compared in two groups after treatment in patients with liver and kidney function changes are better than before treatment, the difference was statistically significant (P0.05). Conclusion Early application of UTI treatment in severe burn patients can significantly improve the efficacy of the heart, liver, kidney and other vital organs to play an active role in the protection, help to improve the quality of life of patients and safe, it is worth used in clinical practice to use.