不同药物减少无痛胃镜检查中依托咪酯所致不良反应的效果比较

摘要

Objective To investigate the effect of different brags in reducing adverse reactions caused by etomidate in painless gastroscopy. Methods One hundred and sixty patients of intravenous general anesthesia undergoing gastroscopy were randomly divided into four groups, with 40 patients in each group: group M (treated by etomidate combined with midazolam), group P (etomidate combined with propofol), group S (etomidate combined with suf-entanil), group E (etomidate). The mean arterial pressure, heart rate and oxygen saturation of blood oxygen saturation were recorded before anesthesia (T0), before sleep (T1) and after operation (T2). The operation time, the time for opening eyes, the orientation recovery time, adverse reactions (myoclonus, myalgia, nausea and vomiting) were recorded. Results The incidences of nausea and vomiting, myalgia in group M, group P and group S were significantly lower than those in group E (P<0.05 ). The incidence of myoclonia in group S was significantly lower than that in group M and group P (P<0.05). Conclusion Midazolam, propofol, sufentanil can effectively reduce the incidence of myoclonus, nausea and vomiting. The clinical efficacy of sufentanil is better.%目的 观察不同药物减少无痛胃镜检查中依托咪酯所致不良反应的效果.方法 160例静脉全麻下行胃镜检查患者,随机分为依托咪酯复合咪达唑仑组(M组)、依托咪酯复合丙泊酚组(P组)、依托咪酯复合舒芬太尼组(S组)和单纯依托咪酯组(E组)各40例.记录四组患者麻醉前(T0)、入睡时(T1)、术后(T2)平均动脉压、心率及血氧饱和度.记录四组患者手术时间、呼唤睁眼和定向力恢复时间,肌阵挛、恶心呕吐、肌痛等不良反应的发生情况.结果 M、P、S组恶心呕吐肌阵挛发生率均低于E组(P＜0.05),S组肌阵挛率发生率低于M、P组(P＜0.05).结论 咪达唑仑、丙泊酚、舒芬太尼均能有效减少依托咪酯所致的肌阵挛、恶心呕吐发生率,尤以舒芬太尼效果为佳.