Objective To observe the curative effect, TGF-β1 change in patients with vasculitis type IgA nephropathy treated by mycophenolate mofetil and prednisone. Methods Eighty-eight patients with vasculitis type IgA nephropathy were divided into two groups. The control group (44 cases) were treated by routine treatment and predni- sone, the observation group (44 cases) were added mycophenolate mofetil and prednisone. We observated the efficacy and the change of TGF-β1 in two groups. Results The total effective rate was obviously higher in the observation group than that in the control group (93.18% vs 77.27%). The change value of TGF-β1 were obviously higher in the observation group after treatment [(65.08±8.63) ng/L vs (40.89±8.32) ng/L]. Conclusion Mycophenolate mofetil and prednisone can improve the curative effect, regulate the expression of TGF-β1 in patients with vasculitis type IgA nephropathy.%目的 探讨强的松联合吗替麦考酚酯治疗血管炎型IgA肾病的疗效及对血清中转化生长因子β1(TGF-β1)的影响.方法 收集我院确诊的88例血管炎型IgA肾病,依患者的入院顺序分为观察组与对照组,观察组44例,在常规治疗基本上加用强的松联合吗替麦考酚酯治疗；对照组44例,在常规治疗基础上加用强的松治疗,观察治疗的效果及治疗前、治疗后血清中TGF-β1的变化.结果 观察组的疗效明显优于对照组(93.18％ vs 77.27％),两组患者治疗后血清中TGF-β1的含量均下降,但是观察组患者的下降值明显高于对照组[(65.08±8.63) ng/L vs(40.89±8.32) ng/L].结论 强的松联合吗替麦考酚酯治疗血管炎型IgA肾病患者临床疗效明显,且能显著降低血清中TGF-β1的含量,值得临床推广应用.
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