Combined Therapy for Non-Resectable Squamous Cell Carcinoma of the Oral Cavity. Local Selective Intra-Arterial Infusion with Adriamycin and Bleomycin Combined Concurrently with Radiotherapy. The Predictive Value of Flow Cytometry in Monitoring Cell Cycle Kinetic Effects of Therapy

摘要

A promising way to acquire information about individual tumor behavior seems to be the determination of cell kinetic properties and, even more importantly, the changes they undergo during treatment. Ideally, knowledge of changes in cell cycle at all times is desirable so that optimal regulation of the chosen chemotherapy and/or radiotherapy could lead to maximal cell death of the tumor cells with minimal toxicity for the host cells. A possible gain for increasing insight into the characteristics of a particular tumor is DNA flow cytometry. By taking multiple biopsies before and during the chemotherapy/radiotherapy treatment, it is perhaps possible to predict the expected clinical results. Research relating to this is described in this dissertation: 16 patients with non-resectable tumors of the oral cavity were treated with concurrent intra-arterial chemotherapy and radiotherapy. Multiple biopsies were analyzed with DNA flow cytometry and an attempt was made to correlate the clinical response with the acquired cellular kinetic data. The purpose of the research can be summarized as: 1. Is regional cure of non-resectable squamous cell carcinomas possible using the method described. 2. Is it possible, using DNA flow cytometry, to predict the chance of successful therapy. 372 references, 38 figures, 33 tables. (Atomindex citation 18:090280)