MBP、抗神经节苷脂抗体与格林-巴利综合征亚型及严重度相关性分析

摘要

Objective To explore the correlation of maltose binding protein (MBP), anti-ganglioside antibod-ies and Guillain-Barre syndrome subtype's severity by detecting serum levels of MBP, anti-ganglioside antibodies in patients with Guillain-Barre syndrome (GBS). Methods Ninety patients with Guillain-Barre syndrome in our hospi-tal from March 2009 to March 2012 were selected as observation group, and 90 patients with neurological diseases were selected as control group 1 and 100 healthy people were chosen as control group 2 at the same time. Then en-zyme-linked immunosorbent assay (ELISA) was used to test the serum levels of MBP and anti-ganglioside antibody in three groups. The results obtained were compared at last. Results (1) The MBP and anti-ganglioside antibodies lev-els in the observation group were significantly higher than those in the control group 1 and control group 2 (P<0.05). The MBP levels in the control group 1 was significantly higher than those in the control group 2 with a statistically sig-nificant difference (P<0.05). (2) There was no difference in the serum MBP level between patients with AIDP and pa-tients with AMAN, AMSAN or MFS (P>0.05). However, the positive rates of serum anti-ganglioside antibodies in pa-tients with AIDP was significantly higher than those in patients with AMAN, AMSAN or MFS with statistically signif-icant differences (P<0.05). (3) The severity of GBS was positive related with the positive rate of MBP and the levels of anti-ganglioside antibodies. Conclusion There is a positive correlation between MBP, anti-ganglioside antibodies and the severity of Guillain-Barre syndrome, and the anti-ganglioside antibodies may be associated with Guil-lain-Barre syndrome subtypes-AIDP.%目的：通过检测格林-巴利综合征(GBS)患者血清麦芽糖结合蛋白(MBP)和抗神经节苷脂抗体水平，探讨其与格林-巴利综合征亚型及严重度的相关性。方法选用2009年3月至2012年3月在我院治疗的格林-巴利综合征患者90例作为观察组，选取同期其他神经系统疾病患者90例作为对照1组和健康体检者100例作为对照2组。采用酶联免疫吸附法(ELISA)检测三组受试者的血清MBP和抗神经节苷脂抗体水平，并进行对比分析。结果(1)观察组血清MBP水平、抗神经节苷脂抗体阳性率均显著高于对照1组和对照2组，其差异均有统计学意义(P<0.05)；对照1组血清中MBP水平显著高于对照2组，两组MBP差异具有统计学意义(P<0.05)。(2)急性炎性脱髓鞘性多发性神经根神经病(AIDP)患者血清MBP水平与急性运动轴索型神经病(AMAN)、急性运动感觉轴索型神经病(AMSAN)及米勒费雪症候群(MFS)比较差异均无统计学意义(P>0.05)；AIDP患者血清抗神经节苷脂抗体阳性率显著高于AMAN、AMSAN及MFS ，其差异均有统计学意义(P<0.05)。(3)病情等级越高GBS患者血清中MBP水平、抗神经节苷脂抗体阳性率越高，不同等级间的差异均有统计学意义(P<0.05)。结论 MBP、抗神经节苷脂抗体与格林-巴利综合征严重度呈正相关，抗神经节苷脂抗体可能与格林-巴利综合征亚型AIDP相关。