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Ganglioside epitopes for treating guillain-barre syndrome
Ganglioside epitopes for treating guillain-barre syndrome
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机译:神经节苷脂表位治疗格林巴利综合征
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摘要
Disclosed are compositions and methods for treating Guillain-Barré syndrome (GBS) in a subject that involves neutralizing specific pathogenic anti-glycolipid antibodies in the circulation of the subject. This can involve administering to the subject a molecular mimic of a ganglioside that serves as a specific competitive inhibitor for anti-ganglioside antibodies in the circulation. Also disclosed is an animal model of GBS having anti-ganglioside antibodies in the circulation.
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