NSCLC组织中nm-23和VEGF蛋白的表达及其临床意义

摘要

Objective To study the expression and significance of nm-23 and vascular endothelial growth factor (VEGF) protein in patients with non-small cell lung cancer (NSCLC). Methods The expression of nm-23 and VEGF protein was detected in tumor tissues of 208 patients with NSCLC, adjacent tissues of 150 patients and lung tis-sues of 17 patients with benign lung disease by tissue microarray and immunohistochemistry. Results ①The expres-sion of nm-23 protein was significantly higher in NSCLC tumor tissues than that in adjacent tissues and benign lung tissues (P<0.01). The difference of nm-23 protein expression between different clinical stages and differentiations was significant (P<0.05).②The expression of VEGF protein was significantly higher in NSCLC tumor tissues than that in adjacent tissues and benign lung tissues (P<0.01). The difference of VEGF protein expression with different differenti-ations, clinical stages and lymph node metastasis was significant (P<0.05). Conclusion ①nm-23 and VEGF protein is highly expressed in NSCLC and associated with the development of NSCLC, so they can be used for early diagno-sis of NSCLC;②nm-23 protein is associated with the clinical stage and differentiation, and VEGF protein is associat-ed with the differentiation, clinical stage and lymph node metastasis.%目的：探讨非小细胞肺癌(NSCLC)组织中nm-23和VEGF蛋白的表达情况及其临床意义。方法通过免疫组化和组织芯片技术，分别检测208例NSCLC患者肿瘤组织、150例癌旁组织及17例良性疾病肺组织中nm-23和VEGF蛋白的表达状况。结果①NSCLC癌组织中nm-23蛋白的表达程度显著高于癌旁组织及良性肺疾病组织(P<0.001)；nm-23蛋白表达程度与NSCL的C临床分期、分化程度相关(P<0.05)。②NSCLC癌组织中VEGF蛋白表达程度显著高于癌旁组织及良性肺疾病组织(P<0.001)；VEGF蛋白表达程度与NSCLC分化程度、临床分期和淋巴结转移与否相关(P<0.05)。结论①NSCLC肿瘤组织中nm-23及VEGF蛋白均呈高表达，提示两者与NSCLC的发生发展密切相关；②NSCLC的临床分期及分化程度与nm-23蛋白表达程度相关， NSCLC的临床分期、分化程度及淋巴结转移与否与VEGF蛋白表达的程度相关，提示两者均与肿瘤恶性生物学行为密切相关。