Objective To evaluate the effect of minocycline hydrochloride on the clinical outcomes of root canal infection in chronic periapical periodontitis. Methods Fifty-four patients (54 teeth) with chronic periapical periodontitis expressing root canal drainage were randomly divided into two groups. Group A (27 cases) were adminis-tered with minocycline hydrochloride, and group B (27 cases), which served as the control, were treated by calcium hydroxide glycerol paste. Inter-appointments pain, changes in exudate and clinical efficacy were compared between the two groups. The clinical curative effects of RCT were evaluated after six months. Results The incidence of in-ter-appointment pain of group A (7.4%) was significantly lower than that of group B (33.3%), P<0.05. The drainage of root cannal in group A was also significantly decreased (P<0.05). There was no significant difference in success rate between group A (96.3%) and group B (88.89%), P>0.05. Conclusion The effect of minocycline hydrochloride on clinical treatment of exudative root canal is superior to that of calcium hydroxide glycerol paste.%目的 评价盐酸米诺环素软膏作为根管消毒剂治疗感染渗出型慢性根尖周炎的临床疗效.方法 随机单盲对照研究,选择54例(患牙54颗)诊断为慢性根尖周炎合并根管渗液的患者,随机分为两组各27例.A组用盐酸米诺环素软膏作根管封药,B组常规用氢氧化钙甘油糊剂作根管封药;比较两组患者约诊间疼痛程度和复诊时根管渗液的变化,并对根管治疗术(RCT)半年后的临床疗效进行评价.结果 A组约诊间疼痛发生率约为7.4%,低于B组的33.3%(P<0.05);A组根管渗液减少程度优于B组(P<0.05);根管充填术后半年,A、B组间患者的治疗有效率分别为96.3%和88.89%,两组间比较差异无统计学意义(P>0.05).结论 盐酸米诺环素软膏在感染渗出性根管封药中应用短期疗效优于氢氧化钙甘油糊剂.
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