Tuberculosis, which caused by Mycobacterium tuberculosis (M.tb), is a serious zoonotic disease. After infected with M.tb, the development and consequence of infection is a dynamic process between the host immune sys-tem and M.tb. The outcome of this struggle was presented by granuloma formation. Therefore, the research about granu-loma formation and function will benefit us from understanding tuberculosis pathogenesis, as the basic and characteristic pathology of tuberculosis. Moreover, the achievements of granuloma research can give us new perspectives on anti-tuber-culosis drugs development.%结核病(TB)是结核分枝杆菌(M.tb)引起的一种危害严重的人兽共患传染病.机体感染M.tb后,感染的发展和转归是宿主的免疫系统和M.tb相互斗争的结果,这种斗争最基本和最主要的病理特征之一是形成肉芽肿.因此,阐明肉芽肿的形态特点及参与肉芽肿形成的因素,揭示肉芽肿形成的动态过程,对研究结核病的发生发展规律及研发新的抗结核药物具有重大意义.本文对结核肉芽肿的特点、功能以及参与结核肉芽肿形成的各种因素进行了综述.
展开▼
