2013-2015年海口地区妇女高危型HPV感染状况

摘要

目的：调查海口地区妇女高危型人乳头瘤病毒(HPV)感染及分布情况，为今后宫颈癌及癌前病变筛查及防治提供依据。方法收集2013年1月至2015年9月在我院就诊的10840例妇女的宫颈脱落细胞，运用Cervista酶切信号放大检测实验行高危型HPV检测及分型组(依据病毒DNA序列相近性分为A5/A6、A7、A9组)。依据年龄分为青年组(20~29岁)，中青年组(30~39岁)，中年组(40~49岁)，中老年组(50~59岁)和老年组(≥60岁)。统计分析高危型HPV感染与各年龄的关系及各型组分布情况。结果10840例标本中共检出高危型HPV阳性者2010例，感染总阳性率为18.54%，以老年组患者感染率最高(27.61%)，其次为中老年组(22.00%)，以中青年组感染率最低(16.87%)，差异有显著统计学意义(P<0.01)。A9组(包括单重及双重)感染率最高(9.65%)，A7组(包括单重及双重)感染率最低(4.65%)，差异有显著统计学意义(P<0.01)。结论海口地区妇女高危型HPV感染率具有随年龄增加而增加的趋势，以A9组感染率最高，对今后HPV疫苗研究及早期筛查治疗提供依据。%Objective To investigate the infection status and distribution situation of high-risk (HR) humanpap-illoma vires (HPV) in women in Haikou to provide evidence for screening and prevention of cervical cancer and precan-cerous lesions in the future. Methods A total of 10 840 women of cervical exfoliated cells from January 2013 to Sep-tember 2015 in our hospital were collected. Cervista HPV HR test was used to detect high-risk HPV and typing (classi-fied into A5/A6, A7 and A9 group based on similarity of the virus DNA sequence). The patients were divided into young group (20 to 29 years old), middle-young-aged group (30 to 39 years old), middle-aged group (40 to 49 years old), middle-elderly-aged group (50 to 59 years old) and elderly group (60 years old or older) on the basis of age. The relationship between high-risk HPV infection and age, and the distribution of each group were statistically analyzed. Results A total of 2 010 positive cases of high-risk HPV were detected in 10 840 cases, and the total positive rate was 18.54%. The infection rate of elderly group was the highest (27.61%), followed by middle-elderly-aged group (22.00%), and the infection rate of middle-young-aged group was the lowest (16.87%), with statistically significant differences (P<0.01). The infection rate of A9 group (both single and dual) was the highest (9.65%), and the infection rate of A7 group (both single and dual) was the lowest (4.65%), with statistically significant differences (P<0.01). Conclusion The infec-tion rate of high-risk HPV of women in Haikou area has a increasing trend with age, and the infection rate of A9 group is the highest, which provides a basis for HPV vaccine research and early screening and treatment of high-risk HPV.