目的：探讨白细胞介素-6(IL-6)基因启动子区-634C/G多态性与广东地区汉族人群糖尿病周围神经病变(DPN)的关系。方法收集2014年1月至2015年1月我院收治的125例2型糖尿病无周围神经病变患者(DPN0组)，83例2型糖尿病周围神经病变患者(DPN组)及101例健康对照者(NC组)，采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法检测其IL-6基因启动子区-634C/G多态性，比较分析各组间基因型频率、等位基因频率以及相关临床资料。结果 DPN0组的GG基因型频率(16.0%)明显高于NC组的4.0%(P<0.05)，DPN0组(34.4%)、DPN组(33.1%)的G等位基因频率均明显高于NC组的22.3%(P<0.05)，但DPN0和DPN两组间G等位基因频率差异无统计学意义(P>0.05)。结论 IL-6基因启动子区-634 G/G基因型不是广东汉族人群DPN发生的遗传危险因素，但G等位基因可能是DPN发生的遗传危险因素之一。%Objective To investigate the association of IL-6 gene promoter region-643C/G polymorphism with diabetic peripheral neuropathy (DPN). Methods The polymerase chain reaction-restriction fragment length polymor-phism (PCR-RFLP) was applied to detect the polymorphism of IL-6 gene promoter region-634 C/G in 125 cases of type 2 diabetes mellitus without DPN (DPN0 group) and 83 cases of type 2 diabetes mellitus with DPN (DPN group), which were treated in our hospital from Jan. 2014 to Jan. 2015, as well as 101 normal controls (NC group). The relative clinical data, genotype frequency and allele frequency were compared between groups. Results The GG genotype frequency was sig-nificantly higher in DPN0 group than NC group (16.0%vs 4.0%, P<0.05). The G allele frequency was significantly higher in DPN0 group (34.4%) and DPN group (33.1%) than NC group (22.3%), P<0.05, with no statistically significant differ-ence between DPN0 group and DPN group (P>0.05). Conclusion The IL-6 promoter region-643G/G genotype is not a genetic risk factor of DPN development, and IL-6-634G allele may be one of the risk factors in DPN development.
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