Objective To explore changes of hypersensitive C-reactive protein (hypersensitive C-reactive protein, hs-CRP), complement C3, prealbumin (PA) and cortisol levels in the progression of cerebral apoplexy. Methods A total of 90 patients with cerebral apoplexy, who admitted to our hospital from March 2014 to March 2015, were selected as study objects. After 1 d, 7 d, 14 d and 30 d of admission, the levels of hs-CRP and complement C3 in the serum were detected by immune turbidimetric method. Meantime, prealbumin and serum cortisol levels were respectively determined by chemical method and chemiluminescence method. The changes of four indicators in the progression of stroke were compared. Results The serum hs-CRP levels of patients with stroke at 7 d [(25.03±5.68) mg/L] and 14 d [(14.26±4.355) mg/L] of admission were significantly improved than 1 d [(6.08±1.17) mg/L] (P<0.05), and the level of serum hs-CRP at the 14 d of admission significantly decreased than that of 7 d (P<0.05). The serum C3 levels of patients at 7 d [(0.62±0.11) g/L] of admission significantly decreased than 1 d [(1.03±0.11) g/L] (P<0.05), and the serum C3 levels of 14 d [(0.82±0.10) g/L] and 30 d [(0.91±0.18) g/L] of admission were not significantly different from 1 d (P>0.05). The level of serum PA at 7 d [(197.68±20.08) g/L] was significantly decreased than 1 d [(287.98±23.56) g/L] (P<0.05), and serum PA level of 14 d of admission [(258.93 ± 23.15) g/L] was significantly increased than 7 d (P<0.05). The serum cortisol levels of 7 d [(496.78±38.99) nmol/L] and 14 d [(467.06±32.58) nmol/L] were significantly increased than 1 d [(397.83±42.06) nmol/L] (P<0.05), and the serum cortisol level of 14 d significantly decreased than 7 d (P<0.05). Stroke severity was positive-ly correlated with severity of nutrient metabolism. Conclusion Hs-CRP, complement C3, PA and cortisol levels and the progression of stroke showed significant temporal correlation, which is reflected most clearly on patients in the acute period.%目的 观察超敏C反应蛋白(hs-CRP)、补体C3、前白蛋白(PA)及皮质醇水平在脑卒中患者疾病进展中的变化情况.方法 收集2014年3月至2015年3月期间我院收治的脑卒中患者90例为研究对象,在患者入院第1天、第7天、第14天和第30天采用免疫比浊法检测患者血清中的hs-CRP、补体C3水平,采用化学方法检测血清中PA水平,采用化学发光法检测血清皮质醇水平,比较上述四种指标在脑卒中患者疾病进展中的变化情况.结果 (1)患者入院后第7天[(25.03±5.68)mg/L]和第14天[(14.26±4.355)mg/L]的血清hs-CRP水平较第1天[(6.08±1.17)mg/L]显著升高,差异有统计学意义(P<0.05),入院第14天的血清Hs-CRP水平较第7天下降,差异有统计学意义(P<0.05);入院后第7天的血清C3水平较第1天显著下降,差异有统计学意义(P<0.05),入院第14天[(0.82±0.10)g/L]、第30天[(0.91±0.18)g/L]的血清C3水平与第1天比较差异无统计学意义(P>0.05);患者入院第7天[(197.68±20.08)g/L]的血清PA水平较第1天[(287.98±23.56)g/L]显著下降,差异有统计学意义(P<0.05),入院第14天[(258.93±23.15)g/L]的血清PA水平较第7天显著上升,差异有统计学意义(P<0.05);患者入院第7天[(496.78±38.99)nmol/L]和第14天[(467.06±32.58)nmol/L]的血清皮质醇水平较第1天[(397.83±42.06)nmol/L]显著上升(P<0.05),第14天的血清皮质醇水平较第7天有所下降(P<0.05).(2)脑卒中严重程度与营养代谢严重程度呈正相关关系.结论 hs-CRP、补体C3、PA和皮质醇水平在脑卒中患者疾病进展中呈现明显的时间相关性,处于急性期的患者变化最为明显.
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