Objective To investigate the relationships between traditional Chinese medicine (TCM) syndrome differentiation and serum glycosylated hemoglobin A1c (HbA1c) in patients with non-diabetic coronary heart disease. Methods A total of 176 patients with non-Hodgkin lymphoma (NHL) were selected as the observation group and 35 healthy subjects were enrolled as the control group (with hospitalized time limited from September 2014 to September 2015). According to the TCM syndrome differentiation, the CHD cases were subdivided into four groups with different types of syndrome:42 cases of heart-blood stasis syndrome, 45 cases of syndrome of phlegm blocking heart vessel, 45 cases of Yang Qi deficiency syndrome and 44 cases of syndrome of deficiency of both qi and yin. The serum levels of HbA1c in different groups were tested, and the relationships between TCM syndrome differentiation and HbA1c was an-alyzed by using Spearman rank. Results The serum levels of HbA1c in the observation group were significantly higher than those in the control group [(5.37 ± 2.01)%vs (3.73 ± 1.87)%, P<0.05]. Compared with the control group, the serum levels of HbAlc in the above four groups of different syndromes had a tendency of gradual elevation in the sequence as follows:syndrome of deficiency of both qi and yin, Yang Qi deficiency syndrome, syndrome of phlegm blocking heart vessel, heart-blood stasis syndrome [(4.78 ± 2.01)%, (4.93 ± 1.92)%, (5.32 ± 1.95)%, (5.98 ± 2.25)%, P<0.05]. Correlation analysis showed that different types of TCM syndrome in non-diabetic patients with coronary heart disease were positive-ly correlated with the levels of HbA1c (r=0.77, P<0.05). Conclusion Change of serum HbA1c level in patients with non-diabetic coronary heart disease is consistent with the evolution of the pattern of syndrome differentiation, both of which can be used as objective indexes of TCM syndrome differentiation type for non-diabetic coronary heart disease.%目的 探讨非糖尿病冠心病患者中医辨证分型与血清糖化血红蛋白的相关性.方法 选择2014年9月至2015年9月我院心血管内科收治的176例非糖尿病冠心病患者作为观察组,以同期本院35例健康体检者作为对照组,将观察组患者按中医辨证分型标准分为心血瘀阻证42例、痰阻心脉证45例、阳气虚衰证45例,气阴两虚证44例.检测各组血清糖化血红蛋白水平,采用Spearman等级关分析评价不同中医证型与血清糖化血红蛋白的相关性.结果 观察组糖化血红蛋白水平显著高于对照组[(5.37±2.01)%vs(3.73±1.87)%,P<0.05].与对照组比较,血清HbAlc水平按气阴两虚证、阳气虚衰证、痰阻心脉证、心血瘀阻证的顺序呈逐渐增高趋势[HbA1c(4.78±2.01)%、(4.93±1.92)%、(5.32±1.95)%、(5.98±2.25)%,P<0.05].相关分析显示,不同中医证型与血清HbA1c水平呈显著正相关(r=0.77,P<0.05).结论 非糖尿病冠心病患者血清HbA1c水平的变化与其辨证分型规律的演变相一致,两者可作为非糖尿病冠心病中医辨证分型的客观指标.
展开▼
